Before Road Runner, an "Acme Company" which controls the production and sale of the fictional element "tungite" appears in the 1940 serial Mysterious Doctor Satan.
In Road Runner
The company is never clearly defined in Road Runner cartoons but appears to be a conglomerate which produces every product type imaginable, no matter how elaborate or extravagant – most of which never work as desired or expected. In the Road Runner cartoon Beep, Beep, it was referred to as "Acme Rocket-Powered Products, Inc." based in Fairfield, New Jersey. Many of its products appear to be produced specifically for Wile E. Coyote; for example, the Acme Giant Rubber Band, subtitled "(For Tripping Road Runners)".
Sometimes, Acme can also send living creatures through the mail, though that isn't done very often. Two examples of this are the Acme Wild-Cat, which had been used on Elmer Fudd and Sam Sheepdog (which doesn't maul its intended victim, but the owner instead); and Acme Bumblebees in one-fifth bottles (which sting Wile E. Coyote). The Wild Cat was used in the shorts Don't Give Up the Sheep and A Mutt in a Rut, while the bees were used in the short Zoom and Bored.
While their products leave much to be desired, Acme delivery service is second to none; Wile E. can merely drop an order into a mailbox (or enter an order on a website, as in the Looney Tunes: Back in Action movie), and have the product in his hands within seconds.